Novoa Laboratory

Epitranscriptomics and RNA Dynamics Lab
Centre for Genomic Regulation (CRG)- Barcelona

About us

We are a multidisciplinary and multicultural laboratory, led by Dr. Eva María Novoa. We study RNA, its modifications, and the importance of epitranscriptomics in biological systems. Our overarching research goals include to understand RNA-mediated inheritance across generations, decipher the role of RNA modifications in health and disease, and design new early diagnostic and prognostic tools for widespread diseases such as cancer.

Publication highlights

(latest publications)

Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing

April 2023

Lucas MC, Pryszcz LP, Medina R, Milenkovic I, Camacho N, Marchand V, Motorin Y, Ribas de Pouplana L, Novoa EM. Nat Biotechnol. 2023 Apr 6. DOI: 10.1038/s41587-023-01743-6

Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart

March 2023

Milenkovic I, Vieira HGS, Lucas MC, Ruiz-Orera J, Patone G, Kesteven S, Wu J, Feneley M, Espadas G, Sabidó E, Hubner N, van Heesch S, Voelkers M and Novoa EM^#.Nucleic Acids Res 2023, doi: /10.1093/nar/gkad121

Nano3P-seq: transcriptome-wide analysis of gene expression and tail dynamics using end-capture nanopore cDNA sequencing

December 2022

Begik O, Diensthuber G, Liu H, Delgado-Tejedor A, Kontur C, Niazi AM, Valen E, Giraldez AJ, Beaudoin JD, Mattick JS and Novoa EM^#. Nat Methods. 2023 Jan;20(1):75-85. DOI: 10.1038/s41592-022-01714-w

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Lab News

Last posts

Merry Xmas from the NovoaLab!

Some pictures from our lab from the CRG Xmas party – Merry Xmas and happy new year to everyone! 🙂

International Lab Lunch

We are a lab of more than 10 different nationalities, so we decided to make an international lab lunch where each of us brought something typical from their nationality… yum!!!

Ivan’s RPL3L paper gets the journal cover!

In Nucleic Acids Research
Congrats Ivan!

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NovoaLab

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Novoa Lab Follow

Tweets from lab members of the Epitranscriptomics & RNA Dynamics lab @CRGenomica

Novoa Lab @novoalab ·

10 Apr

It was a pleasure hosting Jasper Verwilt @JVerwilt from Sleegers Lab @SleegersLab in our lab for 3 weeks, focusing on establishing a Nano3PCR-seq protocol to capture cell-free RNA biomarkers in human biofluids — Jasper it was great having you with us, hope to see you again!🚀

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Novoa Lab @novoalab ·

4 Mar

New preprint released 🪇

Which tRNAs are used by ribosomes during translation?

We introduce tRIBO-seq, a nanopore method to sequence ribosome-associated tRNAs and track how the active tRNA pool changes across stress conditions.

https://www.biorxiv.org/content/10.64898/2026.03.02.709006v1

A thread 🧵

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Novoa Lab @novoalab ·

30 Jan

Please join us in congratulating Gregor @GDiensthuber
on successfully defending his PhD 🎓 A proud moment for the whole lab 🧬 Thanks for being such a great colleague and lab mate! We’re excited to see where your science takes you next! 🚀

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Novoa Lab @novoalab ·

1 Dec

Last week our Lab participated in the @CRGenomica
PhD Symposium! Huge congrats to Cristina Petrella and Leda Katopodi for their successful talks, and @GDiensthuber for reaching the final stage of his PhD! Big thanks to the CRG and the PhD community for a science-packed event👏